Negative Design in Protein Coils
نویسندگان
چکیده
منابع مشابه
Highly specific protein-protein interactions, evolution and negative design.
We consider highly specific protein-protein interactions in proteomes of simple model proteins. We are inspired by the work of Zarrinpar et al (2003 Nature 426 676). They took a binding domain in a signalling pathway in yeast and replaced it with domains of the same class but from different organisms. They found that the probability of a protein binding to a protein from the proteome of a diffe...
متن کاملTheoretical design of 3D gradient coils
Introduction: Gradient coil design is constrained by the important coil parameters of inductance, efficiency and field homogeneity [1]. Additional secondary concerns include reducing the induction of eddy currents and peripheral nerve stimulation, patient claustrophobia and acoustic noise [2]. The search for optimal coil geometries to address various combinations of these design criteria has re...
متن کاملDesign of Dual-Band Double Negative Metamaterials
A dual-band artificial magnetic material and then a dual-band double-negative metamaterial structure based on symmetric spiral resonators are presented. An approximate analytical model is used for the initial design of the proposed structures. The electromagnetic parameters of the proposed metamaterial structure retrieved using an advanced parameter retrieval method based on the causality princ...
متن کاملInhibition of protein crystallization by evolutionary negative design.
Why are proteins so hard to crystallize? We propose an 'evolutionary negative design' principle to explain this difficulty. Proteins have evolved to avoid crystallization because crystallization compromises the viability of the cell. Evolutionary negative design is supported by much evidence in the literature, including the effect of mutations on the crystallizability of a protein, the correlat...
متن کاملModular Design of Coiled Coils to Target bZIP Transcription Factors
Basic leucine-zipper (bZIP) transcription factors regulate many important cellular processes including tissue differentiation, stress responses and the unfolded protein response, the cell cycle, and apoptosis. Understanding the genes and processes regulated by bZIPs is imperative for understanding different diseases including diabetes and cancer, but there is still much unknown about how certai...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2011
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2010.12.3035